The aim of the HyperSpace project is to develop the bioeconomic potential of the medicinal plant Hypericum perforatum L. (St. John’s wort) and related species at various levels. This includes the identification of new genotypes, genes, enzymes, active substances and functions that can be used for the industrial production of higher-value St. John’s wort extracts as well as defined ingredients and prenylated derivatives of other natural substances. The planned development is based on the unique collection of St. John’s wort from the Leibniz Institute of Plant Genetics and Crop Plant Research (IPK). St. John’s wort ( Hypericum perforatum L.), which is primarily used to treat depression but also has antibacterial, anti-cancer and anti-dementia properties, is one of the most important specialty crops in Saxony-Anhalt. The project combines the expertise of various disciplines in Saxony-Anhalt and involves metabolite characterization (Leibniz Institute of Plant Biochemistry, IPB), genome analysis, transcriptomics, developmental biology and cultivation of St. John’s wort (Leibniz Institute of Plant Genetics and Crop Plant Research, IPK), digitalization of the processes (Martin Luther University Halle-Wittenberg, MLU) as well as the socio- and techno-economic evaluation of the products (Fraunhofer IMW). Besides HypericumFurthermore, the establishment of a new technology (SpaceEx) for the spatially resolved recording of tissue-specific gene expression patterns, new Agrobacterium-strains for functional gene validation in plants and an innovative plasmid sequencing method, which are expected to lead to a start-up for synthetic biology in Saxony-Anhalt in the future.